1- Dosage of Clindamycin

• The recommended oral dose of Clindamycin in children with serious infections is 8 to 16 mg/kg/day divided and given every 6 or 8 hours. In those with more severe infections, a higher dose of 16 to 20 mg/kg/day may be used.

2- For capsules and oral solution dosage forms

• Another one of the Important Tips about Clindamycin Usage in Pediatric is in the dosage forms.
  •  Administer without regard to meals, but administer with food if GI upset occurs.
  •  Administer capsules with a full glass of water to reduce esophageal irritation.
  •  Administer the prescribed dose of oral solution using dosing spoon or dosing syringe.

3- The most common side effects of Clindamycin

• As with other antibiotics, Clindamycin use results in substantial changes in bowel microflora and may result in the development of Clostridium Difficile associated diarrhea (CDAD).
• If significant diarrhea occurs during therapy, this antibiotic should be discontinued (see WARNING box).

4- What about the opened capsule:

• it’s can be done but it’s not recommended because Clindamycin irritates the lining of the stomach and intestines  and cause an upset stomach (that’s why it has the capsule.)
• Irritation and scarring of esophageal tissue, by administering tablets or capsules dry, has been known to occur in cats (though not reported in the rat).
• It remains advisable to dissolve the tablet or capsule contents well into food or fluids prior to administering.
• They do have a liquid form which may help if the person has a hard time swallowing pills Some guidelines Prescribe Clindamycin Capsules and label ‘open capsule and mix contents in water and take…Dalacin-C brand capsules suitable for administration via an 8Fr NG tube.

5- What about capsules and intestinal digestion?