Pharmacogenomics Training Certification Program

Welcome to FADIC Pharmacogenomics Training Certification Program!!

• The mission of this program is to improve patient outcomes by maximising efficacy and minimising the toxicity of drug therapy.
• Through understanding the basic concept of pharmacogenomics.
• After you enrol in this program, you can take pharmacogenomics free online course symposium from FADIC as well.

In addition to teaching and service focused on genetically-guided drug therapy decision-making, drug discovery, and drug development.

What is Pharmacogenomics?

• Pharmacogenetics: the study of how genetic differences in a SINGLE gene influence variability in drug response (i.e efficacy and toxicity) by influencing the drug’s PK or PD.

• Pharmacogenomics: the study of how genetic (genome) differences in MULTIPLE genes influence variability in drug response (i.e efficacy and toxicity) by influencing the drug’s PK or PD

• Used interchangeably. The preferred term is Pharmacogenomics

• Firstly, Train clinical and basic scientists in pharmacogenomics.
• Secondly, Educate the concepts of pharmacogenomics, including research findings, potential implications, and implementations.
• Thirdly, Announcement for the FADIC pharmacogenomics initiative that includes various educational initiatives such as seminar series, workshops, research, and symposia.

• Definition of Pharmacogenomics/ Pharmacogenetics
• ‎‏Additionally, genomic achievements since the Human Genome Project and launching of the Personalised Medicine Initiative (PMI) by President Obama in 2015.

2-  All Pharmacogenomics Terminology

3- Clinical Implementation of Pharmacogenomics

• The importance of Pharmacogenomics in enhancing the therapeutic decisions.

•  Clinical relevance of pharmacogenomics.

4- Application of pharmacogenomics in therapeutics (by area)

• CPIC Guidelines
• Examples of drug-gene(s) interactions
• In addition to, pharmacogenomics biomarkers in FDA drug labels

5-  The Business model in pharmacogenomics (cost-effectiveness and Pharmacogenomics)

• Examples of clinical implementation of Pharmacogenomics, e.g. IGNITE, UTHealth Personalized Medicine Program, FDA precision medicine, and Obama Initiatives.
• The Challenges in Pharmacogenomic testing
• Challenges in the clinical implementation of Pharmacogenomics.

6- Your Role in Pharmacogenomics/ personalized medicine.

• How to increase awareness on pharmacogenomics?
• Additionally, recognize useful web tools/ resources/ databases to be able to gather information and answer questions about specific drug-gene(s) interactions.
• Moreover, journal Club Presentations: Pharmacogenomics-related paper to be selected, presented and discussed.
• Finally, the final project of the pharmacogenomics program.

The pharmacogenomics free online course symposium will offer also many examples of clinical application of pharmacogenomics.

• Firstly, The genetic basis of variability in drug efficacy and toxicity, including the study of genetic polymorphisms in drug targets. In addition to the drug transporters, and drug metabolizing enzymes.

• Secondly, This initiative will include the study of the genetic influences on drug pharmacokinetics and pharmacodynamics and will range from polymorphism discovery to in vitro or transgenic functional analysis of polymorphisms to small studies in humans of the functional effects of polymorphisms to large pharmacogenomic clinical trials.

• Finally, Investigation of disease-gene associations, especially those that may have relevance to pharmacogenomics. Use of human genetic information in drug discovery and development.