Off-Label Indications: Prophylaxis or treatment (animal or human bite)/
Acute exacerbation of Bronchiectasis/ COPD
Dosing:
Adult:
Oral: Immediate release: 500 mg every 8 to 12 hours
Extended release: 2 g every 12 hours.
Geriatric: Refer to adult dosing.
Pediatric: _Infants <3 months : 30 mg/kg/day divided every 12 hours
_Children, and Adolescents <40 kg: 25 mg/kg/day in divided doses twice daily OR 45 mg/kg/day in divided doses twice daily (severe infection)
_Children and Adolescents ≥40 kg: 250 mg every 8hours OR 500 mg every 8 hours (severe infection).
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Dose Adjustments:
Renal Impairment: Adult: CrCl 10 to 30 mL/minute: 250 to 500 mg every 12 hours
CrCl <10 mL/minute: 250 to 500 mg every 24 hours
Hepatic Impairment: use with caution
Adverse Drug Interaction:– Diarrhea/ Diaper rash and skin rash/ Vaginitis
Pharmacodynamics/Kinetics:
– Half-life elimination: Immediate-release 61.3 minutes/ Extended-release: 90 minutes
– Time to peak: Capsule 1 to 2 hours, Extended-release: 3.1 hours
– Excretion: Urine (60% as unchanged drugs
Important Notes: Watch for hypersensitivity reactions
Pregnancy & Lactation: category B pregnancy/ Compatible with breastfeeding
Drug safety issue: Augmentin may be confused with amoxicillin, Azulfidine
Augmentin Patient counseling
Tell all of your health care providers that you take this drug
Have your blood work checked if you are on this drug for a long time
This drug may affect certain lab tests. Tell lab workers that you take this drug.
Do not use longer than you have been told. A second infection may happen.
Take a missed dose as soon as you think about it.
Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking this drug.
Tell your doctor if you are pregnant or plan on getting pregnant.
Some people may have very bad and sometimes deadly side effects when taking a drug.
Tell your doctor if you have any signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking.
Common Side Effects of Augmentin
It is common to have diarrhea when taking antibiotics. Rarely, a severe form of diarrhea called C diff–associated diarrhea (CDAD) may happen.
CDAD may happen while you are taking an antibiotic or within a few months after you stop taking it.
Call your doctor right away if you have stomach pain or cramps, very loose or watery stools, or bloody stools.
Do not try to treat diarrhea without first checking with your doctor.
A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen
Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
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