Drug Information Vs. Evidence-Based Medicine


InDrug Information Vs. Evidence-Based Medicine

Evidence-Based Medicine


Practising Evidence-Based Medicine “EBM” is essential in today’s healthcare environment.

  • In short, the model of care offers clinicians a way to achieve the Triple Aim’s Objectives,
  • Firstly, these Objectives are improved quality, patient satisfaction, and reduced costs. 
  • Secondly, health care is growing awareness that a significant time lag occurs in getting research information into practice.
  • Thirdly, several examples of treatments that have been well studied and proven effective that are substantially underutilised, and interventions that have been proven ineffective or harmful continue to be provided.
  • One of the goals of developing and implementing evidence-based clinical practice guidelines is to help speed up the process of getting evidence into practice.
  • In addition, evidence-based medicine is not just about using evidence to design treatment plans; It also encourages a dialogue between patients and providers, so patients can share in the decision-making and make known values and preferences.
  • Together, the patient and provider can determine an appropriate course of action.
  • Additionally, the benefit of this approach is that providers listen to patient concerns and consider them to determine the appropriate treatment plan.
  • Instead of routinely reviewing the contents of dozens of journals for exciting articles, EBM suggests that you target your reading to issues related to specific patient problems.
  • Meanwhile, developing clinical questions and then searching current databases may be a more productive way of keeping current with the literature.
  • To sum up, Evidence-Based Medicine “converts the abstract exercise of reading and appraising the literature into the pragmatic process of using the literature to benefit individual patients while simultaneously expanding the clinician’s knowledge base.”

Definitions of Evidence-Based Medicine

  • Evidence-Based Medicine (EBM) is a philosophy of practice and an approach to decision-making in the clinical care of patients.
  • David Sackett – a medical doctor and a pioneer in EBM – has defined EBM as the “conscientious, explicit.
  • Additionally, the judicious use of current best evidence in making decisions about the care of individual patients”. 

The practice of EBM refers to integrating individual clinical expertise with the best available external clinical evidence from systematic research”.

  • The National Library of Medicine (NLM) introduced the EBM as a medical subject heading (MeSH) to PubMed in 1997.
  • Subsequently, it is broadly defined as medical practice aiming to improve and evaluate patient care requiring the judicious integration of best research evidence with the patient data to make decisions about medical care.
  • Moreover, it helps physicians make a proper diagnosis and devise testing plans.
  • Additionally, select the best possible treatment and method to prevent diseases and develop guidelines for large groups of populations affected by the same condition.
  • “EBM is nothing more than a process of life-long, self-directed learning in which caring for patients creates the need for clinically important information about a diagnosis, prognosis, therapy, and other clinical and health care issues.”
  • EBM is… “an evolutionary progression of knowledge based on the basic and clinical sciences and facilitated by the age of information technology.”

Evidence-Based Medicine


Evolution of Evidence-Based Medicine:

  • Although Evidence is needed daily, physicians usually don’t get it. Lack of time, information overload, and sometimes outdated textbooks may be due to lack of time.

EBM has passed through different stages:

  • Pre-EBM – Passive diffusion – Publish it, and they will come.
  • During the early EBM – Pull diffusion – Teach them to read it, and they will come.
  • Current EBM – Push diffusion – Read it and send it to them.
  • After that, the Future EBM – Prompt diffusion – Read it for them, connect it to their patients.
That sudden interest in EBM stems from:
  • In short, increasing realisation among clinicians that years of experience unaccompanied by updating knowledge can result in declining clinical performance.
  • patients have access to the same literature as the clinician through numerous sources.
  • the need for valid information about a diagnosis, therapy, prognosis and prevention in this era of consumer activism.

Evidence-Based Medicine is a Process – 5 step approach to practising EBM

  • Evidence-Based Medicine – as mentioned before – is a lifelong, problem-based learning process.
  • EBM asks questions, finds and appraises the relevant data, and takes advantage of that information for everyday clinical practice.

This process involves five linked activities:

  • Framing information needs into good, clearly focused answerable clinical questions – via the PICO model.
  • Efficiently tracking down the best evidence with which to answer the question.
  • Critically appraising the evidence or the literature for validity and clinical usefulness & evaluate for applicability of the evidence.
  • Applying the results in clinical practice.
  • Evaluating the performance of the evidence in clinical application & follow-up on any areas for improvements.
  • Those familiar with the literature in drug information practice will recognise that these activities are remarkably similar to the systematic approach to drug information requests. This process is still very similar to the system for drug information questions today.

Evidence-based medicine is not “cookbook” medicine

  • Because it requires a bottom-up approach that integrates the best external evidence with individual clinical expertise and patients’ choices.

Purpose & importance of Evidence-Based Medicine:

  • The purpose and importance of EBM are to provide a more substantial scientific base for clinical practice and to provide consistent, efficient, effective, safe and quality medical care to patients. 
  • Evidence-based medicine (EBM) is an approach used by medical practitioners to optimise clinical decision-making by using the evidence from published results of properly conducted research. EBM is practised to provide a more substantial scientific base for clinical practice and provide consistent, efficient, effective, safe, and quality medical care.
  • Various study designs are meta-analyses, systematic reviews, randomised controlled trials, cohort studies, case-control studies, case series, editorials and expert opinions, and in vivo and in vitro studies.
  • Evidence-based pharmacy improves the pharmacist’s role in healthcare by emphasising a pharmacist-patient relationship and active involvement in the treatment procedure. Proper application of EBM promotes rational medication use.
  • Improper medical care (overuse, underuse and misuse) lead to various factors like drug resistance. Many epidemiological studies highlighted the variations in local medical practices and have confirmed huge differences depending on where the patient receives treatment. 

Difference between Evidence-based medicine & Evidence-based healthcare:

  • It is helpful to make a difference between these two terms. Evidence-Based Medicine is a conceptual approach of the physician in making decisions related to the individual patient.
  • Unlike this, Evidence-Based Health Care is a broader concept that includes an advanced approach to understanding the patients, families and doctors’ beliefs, values and attitudes.
  • Evidence-Based Health Care also relies on evidence, primarily those on a population level.

Levels of Evidence in the Evidence-Based Medicine

  • In short, the healthcare professional needs to consider the data obtained from various sources before making a final decision.
  • In addition, Evidence-based medicine categorises different types of clinical evidence and ranks them according to their strength:
    • Firstly, Evidence was obtained by meta-analysis of several randomised controlled research (RCR).
    • Secondly, Evidence from only one RCR.
    • Thirdly, Evidence from well-designed controlled research RCR.
    • Fourthly, Evidence from one quasi-experimental research.
    • Then, Evidence from non-experimental studies (comparative research, case study), according to some, for example, Textbooks.
    • Finally, Evidence from experts and clinical practice.

Role of Pharmacist in Evidence-Based Medicine

  • Many community pharmacists in developing and underdeveloped countries restrict their role only to dispensing medicines to patients.
  • Proper pharmaceutical care and evidence-based pharmaceutical care is a new concepts for most of these pharmacists.
  • Lack of proper training, time and access to resources are the significant barriers that impede pharmacists from employing evidence-based practice.
  • Moreover, Evidence-Based Medicine helps to promote the rational use of medications making sure that patients receive the right medicine in the correct dose for the proper diagnosis at the right time at the lowest possible cost suitable to their requirements.
  • Besides, the databases used for evidence collection must be reliable, accurate, provide timely information and be updated frequently.
  • In addition, using reputed quality databases like PubMed, Micromedex, etc., is essential.
  • Interestingly, the selected database must preferably answer a wide range of clinical questions and contain information about FDA-approved drugs, drugs under trials, traditional and alternate medications and non-prescription drugs.
  • The EBM-oriented clinicians of tomorrow have three tasks: a) to use evidence summaries in clinical practice; b) to help develop and update selected systematic reviews or evidence-based guidelines in their area of expertise; and c) to enrol patients in studies of treatment, diagnosis and prognosis on which medical practice is based.

Who Benefits from Evidence-Based Medicine?

  • Practitioners – it provides them with current knowledge to assist with decision-making.
  • Researchers – it reduces duplication, identifies research gaps
  • Community – the recipients of evidence-based interventions.
  • Funder – identifies research gaps and priorities.

Role of Pharmacist in EBM:

  • Pharmacist has a significant role in this reA hospital/Community pharmacist is crucial in dispensing the medication prescribed by a physician to the patient. At times, a clinical pharmacist may be asked questions by physicians, nursing personnel and patients regarding drug information.
  • Hence, the pharmacist must have a vast knowledge about various drugs.
  • In addition to their interactions and adverse effects, proper dosage and good communication skills are required.
  •  It is advisable to be adequately aware of newer medical conditions, their diagnosis, prognosis and prevention, etc.
  • Importantly, Pharmacists must educate the patient about the proper usage of drugs while dispensing. Misinformation can be fatal to the health of the patient.
  • Guidelines must be developed in every country to implement evidence-based practice. Regular training and workshops on advanced treatment practices and usage of the latest drug information databases help in improving the pharmacist’s knowledge 

To Conclude,

  • To sum up, Evidence-Based Medicine and evidence-based pharmaceutical care significantly promote rational medication use and decision making.
  • EBM helps detect adverse drug reactions and drug-drug interactions and can be of great use to answer clinical queries.
  • Its good application brings cost-effective and better health care.
  • In short, its real purpose is that by using the best possible evidence, the doctor chooses the best possible solution for his patient.
  • Additionally, wanting to provide him with the optimum health care in every aspect.
  • In addition to using to avoid significant mistakes in treatment.
  • Besides, it raises the quality of provided health care to the patient. In a broader context, it can save the lives of our patients. 
  • Healthcare professionals must employ EBM in their regular practice. Every country must develop proper guidelines to promote the implementation of EBM.
  • In conclusion, clinical and community pharmacists must be trained well with the latest developments in therapeutic practices.

Evidence-Based Medicine

 


Read More:

Copyright ©: All content on FADIC Website, including medical opinion and any other health-related information, and drug Informtation is for informational purposes only