Lidocaine: Side Effects, Dosages, Treatment & Adjustment

Brand Names: Xylocaine
Therapeutic Category of Lidocaine: Antiarrhythmic Agent, Local Anesthetic
Dosage Forms: Tablet, Oral
Use: Labeled Indications: Local and regional anesthesia by infiltration, nerve block, epidural, or spinal techniques; acute treatment of ventricular arrhythmias from myocardial infarction or cardiac manipulation
Dosing : Adult : Anesthesia, local injectable:
Lidocaine 1% or 2% preservative-free solution.
Intraosseous: Initial dose: 40 mg over 1 to 2 minutes; usual adult dose range and maximum: 20 to 50 mg/dose

Dose Adjustments:
Renal Impairment: No dosage adjustment
Hepatic Impairment: Use with caution
Adverse Drug Interaction:
Headache, shivering, radiculopathy, Bradycardia, cardiac arrhythmia, circulatory shock
Additionally, coronary artery vasospasm, edema

Important Notes:
Continuous intra-articular infusion of local anesthetics after arthroscopic or other surgical procedures is not an approved use; chondrolysis (primarily in the shoulder joint) has occurred following infusion, with some cases requiring arthroplasty or shoulder replacement.
Methemoglobinemia: Has been reported with local anesthetics; clinically significant methemoglobinemia requires immediate treatment along with discontinuation of the anesthetic and other oxidizing agents
Pregnancy & Lactation: crosses the placenta / present in breast milk