Montelukast Common Asthma Medication Imporant Information

Montelukast Common Asthma Medication Important Information

Brand Names: Singulair “Montelukast“
Therapeutic Category: Leukotriene Receptor Antagonist as Montelukast
Dosage Forms: Oral / Tablet, Packet
Use: Labeled Indications: Allergic rhinitis (perennial or seasonal)/ Asthma/ Bronchoconstriction, exercise-induced (prevention):
Off-Label Indication: Chronic urticaria/ Urticaria (nonsteroidal anti-inflammatory drug-induced)
Dosing : Adult : Allergic rhinitis (perennial or seasonal): Oral: 10 mg once daily
Asthma: Oral: 10 mg once daily (in the evening)
Chronic urticaria (off-label use): Oral: 10 mg once daily
Pediatric: Allergic rhinitis:Perennial: Oral:
Infants ≥6 months and Children <6 years: 4 mg once daily
Children ≥6 years and Adolescents <15 years: 5 mg once daily
Adolescents ≥15 years: 10 mg once daily
Seasonal: Oral: Children 2 to 5 years: 4 mg once daily
Children ≥6 years and Adolescents <15 years: 5 mg once daily
Adolescents ≥15 years: 10 mg once daily

Dose Adjustments of Montelukast:
Renal Impairment: No dosage adjustment
Hepatic Impairment: No dosage adjustment
Adverse Drug Interaction:
Headache/ dizziness/ Atopic dermatitis/ Abdominal pain
Pharmacodynamics/Kinetics:
Bioavailability: Tablet: 10 mg, Mean: 64%;
Half-life elimination: 2.7 to 5.5 hours
Time to peak: Tablet: 10 mg: 3 to 4 hours
Important Notes:
Postmarketing reports of behavioral changes (eg, abnormal dreams, agitation, aggression, anxiety, attention deficit, depression, disorientation.
In addition to insomnia, irritability, memory disturbances, restlessness, sleep disturbance.
Moreover, suicide ideation/behavior, and tremor) noted in pediatric, adolescent, and adult patients.
Patients instructed to notify the prescriber if behavioral changes occur
Pregnancy & Lactation: an increased risk of teratogenic effects has not been observed with montelukast use / present in breast milk
Medication Safety Issues: Singulair confused with Oralair, SINEquan