Tamsulosin Oral : Uses, Side Effects, Interactions, Warnings
Tamsulosin
Learn More about The Most Famous Drug – Tamsulosin For Prostatic hyperplasia Prescribed by Doctors:
- Brand Names: Flomax
- Therapeutic Category: Alpha 1 Blocker
- Dosage Forms: Tablet, Oral
- Use: Labeled Indications: Benign prostatic hyperplasia
- Off Label: Chronic prostatitis/chronic pelvic pain syndrome in males, Lower urinary tract symptoms (LUTS) in males, Ureteral calculi expulsion, Ureteral stent-related urinary symptoms
- Dosing : Adult : Tamsulosin capsules should be administered 30 minutes following the same meal each day
- Benign prostatic hyperplasia (BPH): Oral: Capsule: Initial and Maintenance: 0.4 mg once daily. If response is inadequate after 2 to 4 weeks, may increase to 0.8 mg once daily. If therapy discontinued or interrupted for several days, restart with 0.4 mg once daily
- Dose Adjustments
- Renal Impairment: no dosage adjustments
- Hepatic Impairment: no dosage adjustments
- Adverse Drug Interaction:
Orthostatic hypotension, Headache, dizziness, Ejaculation failure, Rhinitis
- Pharmacodynamics/Kinetics:
- Absorption: >90%
- Metabolism: Hepatic
- Bioavailability: Fasting: 30% increase
- Half-life elimination: Healthy volunteers: 9 to 13 hours
- Time to peak: Fasting: 4 to 5 hours; With food: 6 to 7 hours
- Important Notes:
- Angina: Discontinue if symptoms of angina occur or worsen.
- May cause significant orthostatic hypotension and syncope, especially with first dose, anticipate a similar effect if therapy interrupted for a few days, if dosage is rapidly increased, or if another antihypertensive drug (particularly vasodilators) or a PDE-5 inhibitor (eg, sildenafil, tadalafil, vardenafil) introduced.
- Pregnancy & Lactation: Pregnancy risk factor B / not known if present in breast milk
- Medication Safety issue:
- Flomax confused with Flonase, Flovent, Foltx, Fosamax
- Tamsulosin confused with tacrolimus, tamoxifen, terazosin
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