Tamsulosin Oral : Uses, Side Effects, Interactions, Warnings


Tamsulosin

Tamsulosin

Learn More about The Most Famous Drug – Tamsulosin For Prostatic hyperplasia Prescribed by Doctors: 


  • Brand Names: Flomax
  • Therapeutic Category: Alpha 1 Blocker
  • Dosage Forms: Tablet, Oral
  • Use: Labeled Indications: Benign prostatic hyperplasia
  • Off Label: Chronic prostatitis/chronic pelvic pain syndrome in males,  Lower urinary tract symptoms (LUTS) in males, Ureteral calculi expulsion, Ureteral stent-related urinary symptoms
  • Dosing : Adult : Tamsulosin capsules should be administered 30 minutes following the same meal each day
  • Benign prostatic hyperplasia (BPH): Oral: Capsule: Initial and Maintenance: 0.4 mg once daily. If response is inadequate after 2 to 4 weeks, may increase to 0.8 mg once daily. If therapy discontinued or interrupted for several days, restart with 0.4 mg once daily

  • Dose Adjustments
  • Renal Impairment: no dosage adjustments
  • Hepatic Impairment: no dosage adjustments
  • Adverse Drug Interaction:
    Orthostatic hypotension, Headache, dizziness, Ejaculation failure, Rhinitis

  • Pharmacodynamics/Kinetics:
  • Absorption: >90%
  • Metabolism: Hepatic
  • Bioavailability: Fasting: 30% increase
  • Half-life elimination: Healthy volunteers: 9 to 13 hours
  • Time to peak: Fasting: 4 to 5 hours; With food: 6 to 7 hours

  • Important Notes:
  • Angina: Discontinue if symptoms of angina occur or worsen.
  • May cause significant orthostatic hypotension and syncope, especially with first dose, anticipate a similar effect if therapy interrupted for a few days, if dosage is rapidly increased, or if another antihypertensive drug (particularly vasodilators) or a PDE-5 inhibitor (eg, sildenafil, tadalafil, vardenafil) introduced.
  • Pregnancy & Lactation: Pregnancy risk factor B / not known if present in breast milk
  • Medication Safety issue:
    • Flomax  confused with Flonase, Flovent, Foltx, Fosamax
    • Tamsulosin confused with tacrolimus, tamoxifen, terazosin

 

Tamsulosin


 

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