Proton Pump Inhibitors

Proton Pump Inhibitors

 

The Most Famous 4 drugs for Proton Pump Inhibitors are:

1- Omeprazole 💊

2- Pantoprazole 💊

3- Esomeprazole 💊

4- Lansoprazole 💊 

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Omeprazole

• Brand Names: Losec
• Therapeutic Category: Proton Pump Inhibitors
• Dosage Forms: Oral Capsule/ Tablet
• Use: Labeled Indications: Duodenal ulcer, Gastric ulcer, Gastroesophageal reflux disease, Heartburn, Helicobacter pylori eradication
• Off-Label: Dyspepsia, NSAID-induced ulcer treatment, NSAID-induced ulcer prophylaxis, Stress ulcer prophylaxis in critically ill patients
• Dosing : Adult: Duodenal ulcer: Oral: 20 mg once daily for 4 weeks; some patients may require an additional 4 weeks.
• Gastric ulcers: Oral: 40 mg once daily for 4 to 8 weeks
• Pediatric : Erosive esophagitis, treatment (short-term): Oral: Infants, Children, and Adolescents: Duration of therapy for infants is up to 6 weeks. The duration of therapy for children and adolescents is 4 to 8 weeks.
• Dose Adjustments
• Renal Impairment:. No dosage adjustment.
• Hepatic Impairment: Mild to severe impairment: 10 mg once daily when used for maintenance of healing of erosive esophagitis
• Adverse Drug Interaction:
  Headache/ Abdominal pain/ diarrhea/ flatulence/ vomiting
• Pharmacodynamics/Kinetics:
• Onset of action: 1 hour
• Time to peak: 0.5 to 3.5 hours
• Duration: Up to 72 hours
• Half-life elimination: 0.5 to 1 hour; hepatic impairment: 3 hours
• Important Notes:
• Use of proton pump inhibitors (PPIs) may increase risk of CDAD(Clostridioides difficile-associated diarrhea ) , especially in hospitalized patients
• Pregnancy & Lactation: Available data have not shown an increased risk of major birth defects/ present in breast milk
• Drug safety issue:

Omeprazole may be confused with aripiprazole, esomeprazole, fomepizole

PriLOSEC may be confused with Plendil, Prevacid, predniSONE, prilocaine

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Pantoprazole

• Brand Names: Protonix
• Therapeutic Category: Proton Pump Inhibitors
• Dosage Forms: Oral /Tablet/ Packet , IV solution Reconstituted
• Use: Labeled Indications: Erosive esophagitis associated with gastroesophageal reflux disease, Maintenance of healing of erosive esophagitis, Pathological hypersecretory conditions, including Zollinger-Ellison syndrome
• Off-Label: DyspepsiaLevel of Evidence ,Helicobacter pylori eradicationLevel of Evidence, Prevention of NSAID-induced ulcersLevel of Evidence, Prevention of rebleeding in peptic ulcer bleed
• Dosing : Adult: Dyspepsia: Oral: 20 to 40 mg once daily for 4 weeks
• Erosive esophagitis associated with GERD:Oral: 40 mg once daily for up to 8 weeks; an additional 8 weeks may be used in patients who have not healed after an 8-week course
• Pediatric : Children 5 to 11 years: Oral: 20 or 40 mg once daily have been shown to reduce severity and frequency of symptoms within 1 week Dose Adjustments
• Renal Impairment:. No dosage adjustment
• Hepatic Impairment: No dosage adjustment
• Adverse Drug Interaction:
  Dizziness, vertigo, headache, Facial edema
• Pharmacodynamics/Kinetics:
• Onset of action: Acid secretion: Oral: 2.5 hours
• Time to peak: 2.5 hours
• Bioavailability: 77%
• Half-life elimination: 1 hour
• Important Notes:
• Use of proton pump inhibitors (PPIs) may increase risk of CDAD(Clostridioides difficile-associated diarrhea ) , especially in hospitalized patients
• Pregnancy & Lactation: Recommendations for the treatment of GERD in pregnancy are available / present in breast milk
• Drug safety issue:

Pantoprazole may be confused with ARIPiprazole

Protonix may be confused with Lotronex, Lovenox, protamine

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Esomeprazole

• Brand Names: Nexium
• Therapeutic Category: Proton Pump Inhibitors
• Dosage Forms: Oral Capsule/Tablet/ Packet , IV solution Reconstituted
• Use: Labeled Indications: Short-term treatment (up to 6 weeks) of erosive esophagitis associated with gastroesophageal reflux disease (GERD)
• short-term treatment (4 to 8 weeks) and maintenance of healing of severe erosive esophagitis
• Adjunctive treatment of duodenal ulcers associated with Helicobacter pylori
• Dosing : Adult: Erosive esophagitis: Initial: 20 to 40 mg once daily for 4 to 8 weeks; if incomplete healing, may continue for an additional 4 to 8 weeks
• Dyspepsia (off-label use): Oral: 40 mg once daily for up to 8 weeks
• Pediatric : Neonatal: Oral: 0.5 mg/kg/dose given once daily for 7 days
• 3 to 5 kg: 2.5 mg once daily for up to 6 weeks
• >5 to 7.5 kg: 5 mg once daily for up to 6 weeks
• >7.5 kg: 10 mg once daily for up to 6 weeks
• Dose Adjustments
• Renal Impairment:. Severe impairment: Use is not recommended
• Hepatic Impairment: Severe impairment: 20 mg once daily
• Adverse Drug Interaction:
  Esophageal varices, Dizziness, drowsiness, headache, irritability
• Pharmacodynamics/Kinetics:
• Onset of action: 1 to 3 hours
• Time to peak: 1.5 to 2 hours
• Bioavailability: Oral: 64 after a single dose
• Half-life elimination: 1 to 1.5 hours
• Important Notes:
• Use of proton pump inhibitors (PPIs) may increase risk of CDAD(Clostridioides difficile-associated diarrhea ) , especially in hospitalized patients
• Pregnancy & Lactation: Recommendations for the treatment of GERD in pregnancy are available / present in breast milk
• Drug safety issue:

Esomeprazole may be confused with ARIPiprazole, omeprazole

NexIUM may be confused with NexAVAR

 

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Lansoprazole

• Brand Names: Prevacid
• Therapeutic Category: Proton Pump Inhibitors
• Dosage Forms: Oral Capsule/ Tablet Disintegrating
• Use: Labeled Indications: Gastroesophageal reflux disease, Zollinger-Ellison syndrome, Peptic ulcer disease
• Off-Label: Dyspepsia, Stress ulcer prophylaxis in critically-ill patients
• Dosing : Adult: Administer 30 to 60 minutes before a meal
• Mild and intermittent symptoms: 15 mg once daily for 8 weeks; if symptoms persist after 8 weeks, increase to 30 mg once daily
• Severe or frequent symptoms: Oral: 30 mg once daily; once symptoms are controlled, continue treatment for at least 8 weeks
• Pediatric : Infants: 1 to 2 mg/kg/day
• Children: 0.7 to 3 mg/kg/day
• Dose Adjustments
• Renal Impairment:. No dosage adjustment.
• Hepatic Impairment: Severe impairment:15 mg once daily
• Adverse Drug Interaction:
  Headache/ Abdominal pain/ constipation/ nausea
• Pharmacodynamics/Kinetics:
• Onset of action: 1 to 3 hours
• Time to peak: 1.7 hours
• Duration: >1 day
• Half-life elimination: 1.5 ± 1 hour
• Important Notes:
• Use of proton pump inhibitors (PPIs) may increase risk of CDAD(Clostridioides difficile-associated diarrhea ) , especially in hospitalized patients
• Pregnancy & Lactation: Available data have not shown an increased risk of major birth defects/ not known if present in breast milk
• Drug safety issue:

Lansoprazole may be confused with aripiprazole, dexlansoprazole

Prevacid may be confused with Pravachol, Prevpac, PriLOSEC, Prinivil

 

 

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