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Efficacy and safety of nintedanib in patients with systemic sclerosis-associated interstitial lung disease treated with mycophenolate: a subgroup analysis of the SENSCIS trial
- In the Safety and Efficacy of Nintedanib in Systemic Sclerosis (SENSCIS) trial, nintedanib reduced the rate of decline in forced vital capacity (FVC) in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD).
- Patients on stable treatment with mycophenolate for at least 6 months before randomisation could participate.
- The aim of this subgroup analysis was to examine the efficacy and safety of nintedanib by mycophenolate use at baseline.
Source: The Lancet
Efficacy and safety of sildenafil added to pirfenidone in patients with advanced idiopathic pulmonary fibrosis and risk of pulmonary hypertension: a double-blind, randomised, placebo-controlled, phase 2b trial
- The benefit of sildenafil in patients with advanced idiopathic pulmonary fibrosis (IPF) at risk of poor outcomes from pulmonary hypertension, whether already present or likely to develop, is uncertain.
- This study aimed to assess the efficacy and safety of sildenafil added to pirfenidone versus placebo added to pirfenidone for 52 weeks in patients with advanced IPF and at risk of group 3 pulmonary hypertension.
Source: The Lancet
Effectiveness of fevipiprant in reducing exacerbations in patients with severe asthma (LUSTER-1 and LUSTER-2): two phase 3 randomised controlled trials
- Fevipiprant, an oral antagonist of the prostaglandin D 2 receptor 2, reduced sputum eosinophils and improved lung function in phase 2 trials of patients with asthma.
- This study aimed to investigate whether fevipiprant reduces asthma exacerbations in patients with severe asthma.
- Although neither trial showed a statistically significant reduction in asthma exacerbations after adjusting for multiple testing, consistent and modest reductions in exacerbations rates were observed in both studies with the 450 mg dose of fevipiprant.
Source: The Lancet
Development of nanoparticle-delivery systems for antiviral agents: A review
- The COVID-19 pandemic has resulted in unprecedented increases in sickness, death, economic disruption, and social disturbances globally.
- This article outlines the major classes of antivirals, summarizes the challenges currently limiting their efficacy, and highlights how nanoparticles can be used to overcome these challenges.
- Recent studies on the application of antiviral nanoparticle-based delivery systems are reviewed and future directions are described.
Source: ScienceDirect
Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19
- Convalescent plasma has been widely used to treat coronavirus disease 2019 (Covid-19).
- Whether convalescent plasma with high antibody levels rather than low antibody levels is associated with a lower risk of death is unknown.
- Among patients hospitalized with Covid-19 who were not receiving mechanical ventilation, transfusion of plasma with higher antiāSARS-CoV-2 IgG antibody levels was associated with a lower risk of death than transfusion of plasma with lower antibody levels.
Source: NEJM
Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure
- The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction.
- Its effect on cardiovascular outcomes is unknown.
- Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo.
Source: NEJM
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FADIC 2021 Pharmacotherapy Daily News
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