4- Thursday Pharmacotherapy News – 27th May

1 – Atorvastatin: A Potential Treatment in COVID-19?

• For patients with COVID-19 admitted to intensive care, giving atorvastatin 20 mg/d did not result in a significant reduction in risk for venous or arterial thrombosis, for treatment with extracorporeal membrane oxygenation (ECMO), or for all-cause mortality compared with placebo in the INSPIRATION-S study.
• However, there was a suggestion of benefit in the subgroup of patients who were treated within 7 days of COVID-19 symptom onset.

Source: Medscape

2 – Human endeavor for anti-SARS-CoV-2 pharmacotherapy: A major strategy to fight the pandemic

• The global spread of COVID-19 constitutes the most dangerous pandemic to emerge during the last one hundred years.
• A drug search strategy consensus in tandem with analysis of currently available information is extremely important for the rapid identification of anti-viral.
• This study examines how certain approved drugs targeting different viruses can play a role in combating this new virus and analyze how they demonstrate efficacy under clinical assessment.

Source: ScienceDirect

3 – The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-19

• Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third coronavirus causing serious human disease to spread across the world in the past 20 years
• The World Health Organization reported that four candidate drugs, including remdesivir, are ineffective or have little effect on COVID-19.
• According to China News, 90 % of Chinese patients with COVID-19 use traditional Chinese medicine (TCM), with an effectiveness rate of 80 %, and no deterioration in patient condition.
• This study describes the advantages of TCM in the treatment of COVID-19 based on clinical evidence and the required methods for its clinical use.

Source: ScienceDirect

4- COVID-19 Vaccines for Children and Teens

• Although fewer children have been infected with COVID-19 compared to adults, children can:
• Be infected with the virus that causes COVID-19
• Get sick from COVID-19
• Spread COVID-19 to others.
• CDC recommends everyone 12 years and older should get a COVID-19 vaccination to help protect against COVID-19.
• Widespread vaccination is a critical tool to help stop the pandemic.
• Getting your child or teen vaccinated can bring you one step closer to enjoying the activities you miss.
• Children 12 years and older are able to get the Pfizer-BioNTech COVID-19 Vaccine.

Source: CDC

5 – Effective drugs used to combat SARS-CoV-2 infection and the current status of vaccines

• Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causal factor of the coronavirus disease 2019 (COVID-19).
• Drug repurposing, portraying patented drugs as a successful drug development technique, could shorten the period and minimize costs relative to de novo drug exploration.
• In this review, they summarizes the current drug and vaccine discovery status against SARS-CoV-2, predicting that these efforts will help create effective drugs and vaccines for SARS-CoV-2.

Source: ScienceDirect

6 – The therapeutic use of quercetin in ophthalmology: recent applications

• Quercetin is a natural flavonol antioxidant found in various plant sources and food samples.
• It is well known for its notable curative effects on the treatment of ophthalmic diseases due to various biological activities, such as antioxidant, anti-inflammatory, and anti-fibrosis activities.
• This review will discuss the latest developments in therapeutic quercetin for the treatment of keratoconus, Graves’ orbitopathy, ocular surface, cataracts, glaucoma, retinoblastoma, and other retinal diseases.

Source: ScienceDirect

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