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Read & Download your Issue of Thursday – February 11 FNN News
Novel approaches for the treatment of methicillin-resistant Staphylococcus aureus: Using nanoparticles to overcome multidrug resistance
- Methicillin-resistant Staphylococcus aureus (MRSA) causes serious infections in both community and hospital settings, with high mortality rates.
- Treatment of MRSA infections is challenging because of the rapidly evolving resistance mechanisms combined with the protective biofilms of S. aureus.
- In this review, they summarize treatment approaches for MRSA, including novel techniques in nanoparticulate designing for better therapeutic outcomes; and facilitate an understanding that nanoparticulate delivery systems could be a robust approach in the successful treatment of MRSA.
Source: ScienceDirect
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer
- Prostate cancer (PC) is the most common malignancy in men worldwide. Here, two series of novel thiohydantoin derivatives of enzalutamide as potent androgen receptor (AR) antagonists were designed and synthesized.
- Among them, compound 31c was identified as an AR antagonist which is 2.3āfold more potent than enzalutamide.
- These data indicate that 31c can be a good lead compound for further structure optimization for the treatment of prostate cancer.
Source: ScienceDirect
Tetraspanins: useful multifunction proteins for the possible design and development of small-molecule therapeutic tools
- Tetraspanins are small membrane proteins with major role in cell signaling.
- Tetraspanins are important actors in proliferative, immunologic and infectious pathological processes.
- In this review, they present the main characteristics of this superfamily, providing a more detailed description of some significant representatives and discuss their relevance as potential targets for the design and development of small-molecule therapeutics in different pathologies.
Source: ScienceDirect
Artificial intelligence in drug discovery and development
- Artificial Intelligence (AI) has recently started to gear-up its application in various sectors of the society with the pharmaceutical industry as a front-runner beneficiary.
- This review highlights the impactful use of AI in diverse areas of the pharmaceutical sectors viz., drug discovery and development, drug repurposing, improving pharmaceutical productivity, clinical trials, etc.
Source: ScienceDirect
Pharmaceutical strategies in the emerging era of antibody-based biotherapeutics for the treatment of cancers overexpressing MET receptor tyrosine kinase
- Cancerous MET overexpression is a common pathological feature manifested by genetic, molecular, and cellular abnormalities.
- Conventional therapeutic antibodies targeting MET, under clinical trials for almost 10 years, have made little progress with various setbacks.
- In this review, they discuss the relevance of MET overexpression and the latest development of bispecific antibodies, antibodyādrug conjugates (ADCs), and their combined products for clinical development.
Source: ScienceDirect
Union is strength: antiviral and anti-inflammatory drugs for COVID-19
- Several clinical trials to treat Coronavirus 2019 (COVID-19) are in progress around the world.
- Some of them rely on clinical experience, whereas others include computational predictions.
- Here, they provide an overview of current efforts in the search for COVID-19 therapies, focusing on structural information of relevant targets.
- They elaborate on a robust pharmacological rationale for the repurposing of existing drugs, highlighting key advantages of dual therapies with antiviral and anti-inflammatory activity.
Source: ScienceDirect
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FADIC 2021 Pharmacotherapy Daily News
(FNN)
Directed By/ Rasha Abdelsalam
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