Read & Download your Issue of Wednesday – February  03 FNN News

Formulary management challenges and opportunities: 2020 and beyond ‐ an opinion paper of the drug information practice and research network of the American College of Clinical Pharmacy

• Formulary management systems in hospitals and health‐systems serve to ensure that medications are rigorously evaluated for efficacy, safety, and value.
• The increased complexity of these systems poses unique challenges and opportunities for the development of innovative formulary management processes.
• In this article the authors review unique formulary aspects of biosimilars, gene therapy, rare disease treatments, outpatient therapies, and formulary‐related challenges/opportunities with drug shortages.

Source: ACCP

Competency‐based clinical pharmacogenomics activities during an advanced pharmacy practice experience

Clinical pharmacogenomics is a required element in the Doctor of Pharmacy (Pharm.D.) curriculum.

This article describe our analysis of clinical pharmacogenomics competency statements and our process of matching these statements with learning activities in our APPE to:

• identify unmet needs, and
• identify essential activities for a clinical pharmacogenomics APPE for students to meet pharmacogenomics competencies.

Source: ACCP

Why Are New SARS-CoV-2 Variants Spreading So Dramatically Around The World?

• A new variant of coronavirus has swept across the United Kingdom and been detected in the United States, Canada and elsewhere.
• Scientists are concerned that these new strains may spread more easily.
• SARS-CoV-2 has been mutating as it spreads, generating slight differences in its genome.
• These mutations allow scientists to trace who is related to whom across the family tree of the virus.
• Never before have we had so much real-time data about evolution as we do with SARS-CoV-2: over 380,000 genomes were sequenced last year.

Source: ScienceAlert

Better Genetic Surveillance of COVID-19 Will Help Us Control The Pandemic, Says WHO

• To monitor changes to the coronavirus that could supercharge the pandemic or render vaccines less effective, scientists must sequence its genetic code to catalogue potentially dangerous mutations as they emerge.
• But so few countries are conducting and sharing surveillance that experts are as worried about the mutations they cannot see as those they can.
• Publication of the first genomic sequence of SARS-CoV-2 in January last year, at the very outset of the pandemic, allowed scientists to identify it as a new coronavirus, and begin developing diagnostic testing and vaccines.

Source: ScienceAlert

The Proportion of SARS-CoV-2 Infections That Are Asymptomatic

• Asymptomatic infection seems to be a notable feature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen that causes coronavirus disease 2019 (COVID-19), but the prevalence is uncertain.
• This study aims to estimate the proportion of persons infected with SARS-CoV-2 who never develop symptoms.
• Available data suggest that at least one third of SARS-CoV-2 infections are asymptomatic.
• Longitudinal studies suggest that nearly three quarters of persons who receive a positive PCR test result but have no symptoms at the time of testing will remain asymptomatic.

Source: Annals of Internal Medicine

Deadly Bacteria Could Be Sharing Antibiotic Resistance Faster Than We Thought

• Antibiotics have saved countless lives over the decades. Yet to the pathogens they kill, antibiotics are an ancient foe, one they are already adept at fighting.
• It turns out the spread of antibiotic resistance might not be as constrained as we assumed, giving more species far easier access to antibiotic resistance than previous models would have us believe.

Source: ScienceAlert

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