3- Wednesday Research News – 17th March

1 – Economic Benefits of COVID-19 Screening Tests with a Vaccine Rollout

• This note estimates the costs and benefits of a nationwide COVID-19 screening testing program in the presence of vaccine distribution.
• Even for an optimistic vaccine rollout scenario, a well- funded screening testing program, coupled with self-isolation of those who test positive, pays for itself in terms of increased GDP and is projected to save 20,000 or more lives.
• The sooner the testing program is put in place, the greater are its net economic benefits.

Source: Medrxiv

2- Persistence of symptoms up to 10 months following acute COVID-19 illness

• COVID-19 symptoms are increasingly recognized to persist among a subset of individual following acute infection, but features associated with this persistence are not well-understood.
• They aimed to identify individual features that predicted persistence of symptoms over at least 2 months at the time of survey completion.
• A subset of individuals experience persistent symptoms from 2 to more than 10 months after acute COVID-19 illness, particularly those who recall headache and absence of fever.

Source: MedRxiv

3- Long-term clinical, virological and immunological outcomes in patients hospitalized for COVID-19: antibody response predicts long COVID.

• Long-term data following SARS-CoV-2 infection are limited.
• This study aimed to characterize the medium and long-term clinical, virological, and immunological outcomes after hospitalization for COVID-19, and to identify predictors of long-COVID.
• Late clinical events and persistent symptoms in the medium and long term occurred in a significant proportion of patients hospitalized for COVID-19.
• Gender, severity of illness and weaker antibody responses, but not viral shedding, were associated with long-COVID.

Source: MedRxiv

4- COVID-19 Presenting With Diabetic Ketoacidosis: A Case Series

• Diabetes mellitus has been recognized as one of the comorbidities that predict the severity of illness in patients infected with COVID-19.
• The characteristics of patients presenting with diabetic ketoacidosis (DKA) and COVID-19 infection have not been described.
• While DKA with an infectious etiology is a common presentation, they observed that the patients with DKA precipitated by COVID-19 presented with atypical symptoms.

Source: ScienceDirect

5- Pembrolizumab-Associated Hypoparathyroidism: A Single Case Report

• This study aims to evaluate a case of pembrolizumab-induced hypoparathyroidism leading to hypocalcemia.
• Pembrolizumab treatment may have resulted in immune-mediated hypoparathyroidism, leading to hypocalcemia.
• It is important to report such cases to understand its presentation and timing in relation to pembrolizumab, which further facilitates its timely treatment.

Source: ScienceDirect

6- Tumor-Induced Hypoglycemia: An Unusual Case Report and Review of Literature

• This study aims to describe a rare case of pheochromocytoma presenting with hypoglycemia.
• The patient had non–islet-cell tumor hypoglycemia that was non-insulin mediated, as noted by low insulin levels.
• His hypoglycemia was likely multifactorial and mediated by different mechanisms.
• They describe the rare case and review the causes of tumor-induced hypoglycemia.

Source: ScienceDirect

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