Read & Download your Issue of Wednesday – February  24 FNN News

Optimal symptom combinations to aid COVID-19 case identification: analysis from a community-based, prospective, observational cohort

• Diagnostic work-up following any COVID-19 associated symptom will lead to extensive testing, potentially overwhelming laboratory capacity whilst primarily yielding negative results.
• This study aimed to identify optimal symptom combinations to capture most cases using fewer tests with implications for COVID-19 vaccine developers across different resource settings and public health.

Source: ScienceDirect

Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial

• This study aims to determine whether tocilizumab improves clinical outcomes for patients with severe or critical coronavirus disease 2019.
• In patients with severe or critical covid-19, tocilizumab plus standard care was not superior to standard care alone in improving clinical outcomes at 15 days, and it might increase mortality.

Source: The BMJ

Variant analysis of SARS-CoV-2 genomes in the Middle East

• Coronavirus (COVID-19) was introduced into society in late 2019
• The phylogenetic and variant analysis provides unique insight into mutation types in SARS-Cov2 genomes in middle east.
• This study aims to analyse the variants of severe acute respiratory syndrome coronavirus-2 (SARS -CoV-2) to characterise the common genome variants and provide useful data in the global effort to prevent further spread of COVID-19.

Source: ScienceDirect

Persistence of SARS-CoV-2 specific B- and T-cell responses in convalescent COVID-19 patients 6-8 months after the infection

• Monitoring the adaptive immune responses during the natural course of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection provides useful information for the development of vaccination strategies against this virus and its emerging variants.
• This study profiled the serum anti-SARS-CoV-2 antibody levels and specific memory B- and T-cell responses in convalescent coronavirus disease-2019 (COVID-19) patients.
• Our data suggest that protective adaptive immunity following natural infection of SARS-CoV-2 might persist for at least 6-8 months

Source: ScienceDirect

Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial

• Effective antiviral drugs for COVID-19 are still lacking.
• This study aims to evaluate the clinical outcomes and plasma concentrations of baloxavir acid and favipiravir in COVID-19 patients.
• These findings could not prove a benefit of addition of either baloxavir marboxil or favipiravir under the trial dosages to the existing standard treatment.

Source: ScienceDirect

COVID-19 and Acute Pulmonary Embolism: A Case Series and Brief Review

• The SARS-CoV-2 virus, or COVID-19, is responsible for the current global pandemic
• Here they report a case-series of COVID-19 patients with diverse presentations of pulmonary embolism (PE) at our institution.
• They also briefly describe the pathophysiology and mechanisms for pulmonary embolism in COVID-19.
• These cases indicate a need to maintain a high index of suspicion for PE in patients with COVID-19, as well as the need to consider occult COVID-19 infection in patients with PE in the right clinical circumstance.

Source: ScienceDirect

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